Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTIODT03)

DOT Name Poly(A) polymerase alpha (PAP)
Synonyms PAP-alpha; EC 2.7.7.19; Polynucleotide adenylyltransferase alpha
Gene Name PAP
UniProt ID
PAPOA_BOVIN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1F5A; 1Q78; 1Q79
EC Number
2.7.7.19
Pfam ID
PF04928 ; PF20750 ; PF04926
Sequence
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCLLTQKLVETLKPFGVFEEEEELQR
RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
MKIAAMHVKRKQLHQLLPSHVLQKKKKHSTEGVKLTPLNDSSLDLSMDSDNSMSVPSPTS
AMKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSLPQINSSESSGGTSSESIPQTAT
QPAISSPPKPTVSRVVSSTRLVNPPPRPSGNAAAKIPNPIVGVKRTSSPHKEESPKKTKT
EEDETSEDANCLALSGHDKTETKEQLDTETSTTQSETIQTATSLLASQKTSSTDLSDIPA
LPANPIPVIKNSIKLRLNR
Function
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.
Reactome Pathway
Processing of Capped Intron-Containing Pre-mRNA (R-BTA-72203 )
RNA Polymerase II Transcription Termination (R-BTA-73856 )
Processing of Intronless Pre-mRNAs (R-BTA-77595 )
mRNA 3'-end processing (R-BTA-72187 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Poly(A) polymerase alpha (PAP) increases the Cytogenetic abnormality ADR of Acetaminophen. [1]
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References

1 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.