Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTJVFMAS)

• DOT Name: Protein Niban 3 (NIBAN3)
• Synonyms: B-cell novel protein 1; Niban-like protein 2; Protein FAM129C
• Gene Name: NIBAN3
• Related Disease: Advanced cancer
• UniProt ID: NIBA3_HUMAN
• Sequence:
  MGPDRKEVPLSRGTQAVVVGKGRGAPGDDSSMGGRPSSPLDKQQRQHLRGQVDTLLRNFL
  PCYRGQLAASVLRQISRELGPQEPTGSQLLRSKKLPRVREHRGPLTQLRGHPPRWQPIFC
  VLRGDGRLEWFSHKEEYENGGHCLGSTALTGYTLLTSQREYLRLLDALCPESLGDHTQEE
  PDSLLEVPVSFPLFLQHPFRRHLCFSAATREAQHAWRLALQGGIRLQGIVLQRSQAPAAR
  AFLDAVRLYRQHQGHFGDDDVTLGSDAEVLTAVLMREQLPALRAQTLPGLRGAGRARAWA
  WTELLDAVHAAVLAGASAGLCAFQPEKDELLASLEKTIRPDVDQLLRQRARVAGRLRTDI
  RGPLESCLRREVDPQLPRVVQTLLRTVEASLEAVRTLLAQGMDRLSHRLRQSPSGTRLRR
  EVYSFGEMPWDLALMQTCYREAERSRGRLGQLAAPFGFLGMQSLVFGAQDLAQQLMADAV
  ATFLQLADQCLTTALNCDQAAQRLERVRGRVLKKFKSDSGLAQRRFIRGWGLCIFLPFVL
  SQLEPGCKKELPEFEGDVLAVGSQALTTEGIYEDVIRGCLLQRIDQELKKTLGANDVSCT
  LDGCLEVPWEQEGAAPNLNLVSSFLAGRQAFTDFLCLPAKSSANWILAASLLSCSCFRSG
  FHRDSRVFLVQLAEGLSHSLETVSSHSVWSFRPTPRQ
• Tissue Specificity: Specifically expressed in B-lymphocytes.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Advanced cancer	DISAT1Z9	Strong	Posttranslational Modification	[1]

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the mutagenesis of Protein Niban 3 (NIBAN3).	[2]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A increases the expression of Protein Niban 3 (NIBAN3).	[3]

References

• [1] The possible roles of B-cell novel protein-1 (BCNP1) in cellular signalling pathways and in cancer.J Cell Mol Med. 2017 Mar;21(3):456-466. doi: 10.1111/jcmm.12989. Epub 2016 Sep 29.
• [2] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [3] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.