Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTKGRXC4)

DOT Name	7-ethoxycoumarin O-deethylase (CYP76B1)
Synonyms	ECOD; EC 1.14.-.-; Cytochrome P450 76B1; Phenylurea dealkylase
Gene Name	CYP76B1
UniProt ID	C76B1_HELTU
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	1.14.-.-
Pfam ID	PF00067
Sequence	MDFLIIVSTLLLSYILIWVLGVGKPKNLPPGPTRLPIIGNLHLLGALPHQSLAKLAKIHG PIMSLQLGQITTLVISSATAAEEVLKKQDLAFSTRNVPDAVRAYNHERHSISFLHVCTEW RTLRRIVSSNIFSNSSLEAKQHLRSKKVEELIAYCRKAALSNENVHIGRAAFRTSLNLLS NTIFSKDLTDPYEDSGKEFREVITNIMVDSAKTNLVDVFPVLKKIDPQGIKRGMARHFSK VLGIFDQLIEERMRTGRFEQGDVLDVCLKMMQDNPNEFNHTNIKALFLDLFVAGTDTTSI TIEWAMTELLRKPHIMSKAKEELEKVIGKGSIVKEDDVLRLPYLSCIVKEVLRLHPPSPL LLPRKVVTQVELSGYTIPAGTLVFVNAWAIGRDPTVWDDSLEFKPQRFLESRLDVRGHDF DLIPFGAGRRICPGIPLATRMVPIMLGSLLNNFDWKIDTKVPYDVLDMTEKNGTTISKAK PLCVVPIPLN
Function	Capable of dealkylating a model xenobiotic compound, 7-ethoxycoumarin. Metabolizes with high efficiency a wide range of xenobiotics, including alkoxycoumarins, alkoxyresorufins, and several herbicides of the class of phenylureas. Catalyzes the double N-dealkylation (oxidative N-demethylation) of phenylureas such as chlortoluron and isoproturon with turnover rates comparable to those reported for physiological substrates and produces non-phytotoxic compounds. Could be used for control of herbicide tolerance and selectivity, as well as soil and groundwater bioremediation.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	7-ethoxycoumarin O-deethylase (CYP76B1) increases the Renal impairment ADR of Acetaminophen.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.