Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTKL5S1B)

DOT Name	Tryptophan 5-hydroxylase 2 (TPH2)
Synonyms	EC 1.14.16.4; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
Gene Name	TPH2
UniProt ID	TPH2_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
PDB ID	4V06; 7QRI; 7WIY
EC Number	1.14.16.4
Pfam ID	PF00351
Sequence	MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA LNKMNQYLGI
Tissue Specificity	Brain specific.
KEGG Pathway	Tryptophan metabolism (hsa00380 ) Folate biosynthesis (hsa00790 ) Metabolic pathways (hsa01100 ) Serotonergic sy.pse (hsa04726 )
Reactome Pathway	Serotonin and melatonin biosynthesis (R-HSA-209931 )
BioCyc Pathway	MetaCyc:HS06603-MONOMER

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Fluoxetine	DM3PD2C	Approved	Tryptophan 5-hydroxylase 2 (TPH2) affects the response to substance of Fluoxetine.	[3]
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1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate affects the expression of Tryptophan 5-hydroxylase 2 (TPH2).	[1]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Tryptophan 5-hydroxylase 2 (TPH2).	[2]
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References

1	Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
2	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
3	Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacol Biochem Behav. 2006 Sep;85(1):220-7. doi: 10.1016/j.pbb.2006.08.004. Epub 2006 Sep 18.