Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTKMB3SZ)

DOT Name	Protein FAM9C (FAM9C)
Gene Name	FAM9C
Related Disease	Hepatocellular carcinoma ( )
UniProt ID	FAM9C_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF04803
Sequence	MAAKDQLEVQVMAAQEMELAGKDPVSHEHEERKPVTETKEGDVTDEHGERGSFAETDEHT GVDTKELEDIAADIKEHLAAKRKRIEKIAKACSEIKNRIKNVLRTTQLKRQKRDYRISLK LPNVLEEFITDEQKDEEGDGEKEEQIKIFQEQQKRWQQDGKGTERD
Tissue Specificity	Expressed exclusively in testis.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Hepatocellular carcinoma	DIS0J828	Strong	Biomarker	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the expression of Protein FAM9C (FAM9C).	[2]
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References

1	FAM9C plays an anti-apoptotic role through activation of the PI3K/Akt pathway in human hepatocellular carcinoma.Oncol Rep. 2013 Sep;30(3):1275-84. doi: 10.3892/or.2013.2592. Epub 2013 Jul 5.
2	Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.