Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTM2WDDR)

DOT Name	Nuclear pore complex-interacting protein family member B15 (NPIPB15)
Synonyms	Nuclear pore complex-interacting protein-like 2
Gene Name	NPIPB15
UniProt ID	NPB15_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF06409
Sequence	MRLRFWLLIWLLLGFISHQPTPVINSLAVYRHRETDFGVGVRDHPGQHGKTPSPQKLDNL IIIIIGFLRRDTFTILFCTSYLCVSFLKTIFWSRNGHDGSTDVQQRAWRSNRSRQKGLRS ICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINRHDKINGKRKTAR KQKMFQRAQELRRRAEDYHKCKIPPSARKPLCNWVRMAAAEHRHSSGLPCWPYLTAEALK NRMGRQPPPPTQQHSITDNSLSLKTPPECLLHPLPPSVDDNIKECPLAPLPPSVDDNLKE YLLVPLPPSPLPPSVDDNLKDCLFVPLPPSPLPPSVDDNLKTPPLATQEAEAEKPPKPKR WRVDEVEQSPKPKRRRADEVEQSPKPKRQREAEAQQLPKPKRRRLSKLRTRHCTQAWAIR INPWVEKKKKIKKQNKTHAPKTN

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

2 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Estradiol	DMUNTE3	Approved	Estradiol affects the expression of Nuclear pore complex-interacting protein family member B15 (NPIPB15).	[1]
Formaldehyde	DM7Q6M0	Investigative	Formaldehyde increases the expression of Nuclear pore complex-interacting protein family member B15 (NPIPB15).	[2]
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References

1	Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
2	Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.