Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTM3771T)

DOT Name	Histidine decarboxylase (hdc)
Synonyms	HDC; EC 4.1.1.22
Gene Name	hdc
UniProt ID	DCHS_RAOOR
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	4.1.1.22
Pfam ID	PF00282
Sequence	NGGTEGNMFGCYLGREIFPNGTLYYSKDTHYSVAKIVKLLRIKSTLVESQPNGEMDYADL IKKIKRDNEKHPIIFANIGTTVRGAIDNIAIIQQSISELGIERKDYYLHADAALSGMILP FVDNPQPFNFADGIDSIGVSGHKMIGSPIPCGIVVAKKKNVDRISVEIDYISAHDKTISG SRNGHTPLMMWEAIRSHSWEEWRRRIERSLNMAQYAVDRFQSAGIDAW

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Dexamethasone	DMMWZET	Approved	Histidine decarboxylase (hdc) increases the Gastrointestinal disorders ADR of Dexamethasone.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.