Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTMOASTL)

DOT Name	Lysozyme-like protein 2 (LYZL2)
Synonyms	Lysozyme-2; EC 3.2.1.17
Gene Name	LYZL2
Related Disease	Dental caries ( )
UniProt ID	LYZL2_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	3.2.1.17
Pfam ID	PF00062
Sequence	MKAAGILTLIGCLVTGAESKIYTRCKLAKIFSRAGLDNYWGFSLGNWICMAYYESGYNTT AQTVLDDGSIDYGIFQINSFAWCRRGKLKENNHCHVACSALVTDDLTDAIICAKKIVKET QGMNYWQGWKKHCEGRDLSDWKKDCEVS
Tissue Specificity	Expressed in testis, epididymis and placenta.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance		REF
Dental caries	DISRBCMD	Limited	Biomarker	[1]
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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A increases the expression of Lysozyme-like protein 2 (LYZL2).	[2]
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References

1	Clinical application of genetics to guide prevention and treatment of oral diseases.Clin Genet. 2014 Jul;86(1):44-9. doi: 10.1111/cge.12396. Epub 2014 May 10.
2	Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.