Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTMRAJRZ)

DOT Name Testis-specific serine/threonine-protein kinase 4 (TSSK4)
Synonyms TSK-4; TSSK-4; Testis-specific kinase 4; EC 2.7.11.1; Serine/threonine-protein kinase 22E
Gene Name TSSK4
Related Disease
Male infertility ( )
UniProt ID
TSSK4_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
2.7.11.1
Pfam ID
PF00069
Sequence
MGKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKK
ASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGAC
SEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVG
CSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFD
DTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQ
PTHEIRLLEAMCQLHNTTKQHQSLQITT
Function
Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'.
Tissue Specificity Expressed only in the testis.

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Male infertility DISY3YZZ Strong Genetic Variation [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Quercetin DM3NC4M Approved Quercetin increases the expression of Testis-specific serine/threonine-protein kinase 4 (TSSK4). [2]
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of Testis-specific serine/threonine-protein kinase 4 (TSSK4). [3]
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References

1 Mutation screening and association study of the TSSK4 Gene in Chinese infertile men with impaired spermatogenesis.J Androl. 2008 Jul-Aug;29(4):374-8. doi: 10.2164/jandrol.107.004598. Epub 2008 Apr 3.
2 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
3 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.