Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTMTFC76)

DOT Name	NADP-dependent oxidoreductase 3 (nor3)
Gene Name	nor3
UniProt ID	W4JPE0_HETIT
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF16884 ; PF00107
Sequence	MSPITNSRTLFNEVPIGYPEPGRTTIHDTSMSIDLETEPLKGGFLVKTLVLSIDPYLRGK MREATKASYSAPFAKGEPITNFGIGVVLRSEHSGIKVGDHIYGVLPFQEYFVRSDASSFA VIANEEGLPWSVYIGMAGMPGQTAYVGWNEFSKAKKGETAFITTAAGPVGSFVVQLAKLD GLKVIASAGSDEKVEFVRSLGADVVFNYKKESTEEVLQREGGLDIYWDNVGGETLDLALK YANKRARFIECGMITTYNNPDGYGVKNLAEIFKKDMSMHGFINGNWFGKYREQFYQEVPK LVKEGKIQYQEDITRGLEHAGQGILDVQQGTNKGKKVILVADE

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Nitric Oxide	DM1RBYG	Approved	NADP-dependent oxidoreductase 3 (nor3) increases the Apoptosis ADR of Nitric Oxide.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.