Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTMVTCCR)

DOT Name Pleckstrin homology domain-containing family G member 7 (PLEKHG7)
Synonyms PH domain-containing family G member 7
Gene Name PLEKHG7
UniProt ID
PKHG7_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15720 ; PF16652 ; PF00621
Sequence
MEKTESFCPEVPPQDCGASPRPSLRSLPKNQGSLLQFDRQAPGRISTSPTLRRLRTRGCG
TRQDAWQVTTWGSWGAPVGFPCYLSKSLPGSPKDSSHLLSPLRLHSRLTSEPERALNAAD
SLEPQTRPTDKYLPPELQPVNEGSLHQASLRQQEGHFLPSPTLRHPSPQGEELHPSRFYE
HRRSSVVLNLPGLEVFPGDLLVSDGAADYLCHPLLLLNSESKKPRWPFSKRGVGKDKHKH
ISDLENCLSSVKITSFRGYDFYGLKDKTWDEVLETHHKLPTDQLDLKKQQEAVWELFTSE
CTYFLDHLLVLKMIFMNTLRYLQTHEYLLDVDLWRLFANLEELTQTSLGFVNSLFGIIKD
YVDASEISSSLDFISVLTKYFRGSLCQSHQTYCLNYSAAIFYLESLRQRDDFGIYLKWCE
QNEQCRRLHVPELLVAPLQRLTRYPLLLKNIWKRSMDSAEKIMIYSIKEKVEKSIRDLEG
KVKWLDNFQKFRYLQEIIVWPPLWDRDKRFFIPECLKHIFKEHMAENILSPTSRHLLYEG
KLTLAESTRFLDVYLFLFNDFLLVTKTKCNKKKLGGSDPGLMCPSLTPELQAVIKEGGSC
TVLDQPIPLDRLVVKSIEPLHVSVFGLRNAFLIQHENRYRQCIAAFLLQAQTENIKKTWM
AQITTAISCFTKSQETKKISLFTLPAESSEI

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Zoledronate DMIXC7G Approved Zoledronate increases the expression of Pleckstrin homology domain-containing family G member 7 (PLEKHG7). [1]
PMID28460551-Compound-2 DM4DOUB Patented PMID28460551-Compound-2 decreases the expression of Pleckstrin homology domain-containing family G member 7 (PLEKHG7). [3]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Pleckstrin homology domain-containing family G member 7 (PLEKHG7). [2]
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References

1 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
2 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
3 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.