Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTN16PNF)

DOT Name Myosin light chain kinase family member 4 (MYLK4)
Synonyms EC 2.7.11.1; Sugen kinase 85; SgK085
Gene Name MYLK4
Related Disease
Malaria ( )
UniProt ID
MYLK4_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
2X4F
EC Number
2.7.11.1
Pfam ID
PF00069
Sequence
MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSN
ADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQV
HKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVM
EYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDA
KQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGL
SPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPW
LSDHKLHSRLNAQKKKNRGSDAQDFVTK
KEGG Pathway
Calcium sig.ling pathway (hsa04020 )
cGMP-PKG sig.ling pathway (hsa04022 )
Vascular smooth muscle contraction (hsa04270 )
Apelin sig.ling pathway (hsa04371 )
Focal adhesion (hsa04510 )
Platelet activation (hsa04611 )
Regulation of actin cytoskeleton (hsa04810 )
Oxytocin sig.ling pathway (hsa04921 )
Gastric acid secretion (hsa04971 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Malaria DISQ9Y50 Strong Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Myosin light chain kinase family member 4 (MYLK4). [2]
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2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Myosin light chain kinase family member 4 (MYLK4). [3]
Bisphenol A DM2ZLD7 Investigative Bisphenol A increases the methylation of Myosin light chain kinase family member 4 (MYLK4). [4]
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References

1 First genome-wide association study of non-severe malaria in two birth cohorts in Benin.Hum Genet. 2019 Dec;138(11-12):1341-1357. doi: 10.1007/s00439-019-02079-5. Epub 2019 Oct 30.
2 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
3 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
4 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.