Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTNVADE7)

• DOT Name: Ribosome biogenesis protein SLX9 homolog (SLX9)
• Gene Name: SLX9
• UniProt ID: SLX9_HUMAN
• PDB ID: 7WTS; 7WTT; 7WTU; 7WTV; 7WTW
• Pfam ID: PF15341
• Sequence:
  MGKVRGLRARVHQAAVRPKGEAAPGPAPPAPEATPPPASAAGKDWAFINTNIFARTKIDP
  SALVQKLELDVRSVTSVRRGEAGSSARSVPSIRRGAEAKTVLPKKEKMKLRREQWLQKIE
  AIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAGSRRQARSRESNKPRPSELSR
  MSAAQRQQLLEEERTRFQELLASPAYRASPLVAIGQTLARQMQLEDGGQL
• Function: May be involved in ribosome biogenesis.
• Tissue Specificity: Not detected in any tested tissue.

Molecular Interaction Atlas (MIA) of This DOT

4 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Ribosome biogenesis protein SLX9 homolog (SLX9).	[1]
TAK-243	DM4GKV2	Phase 1	TAK-243 increases the sumoylation of Ribosome biogenesis protein SLX9 homolog (SLX9).	[5]
PMID28870136-Compound-52	DMFDERP	Patented	PMID28870136-Compound-52 decreases the phosphorylation of Ribosome biogenesis protein SLX9 homolog (SLX9).	[6]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the methylation of Ribosome biogenesis protein SLX9 homolog (SLX9).	[7]

4 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Tretinoin	DM49DUI	Approved	Tretinoin decreases the expression of Ribosome biogenesis protein SLX9 homolog (SLX9).	[2]
Menadione	DMSJDTY	Approved	Menadione affects the expression of Ribosome biogenesis protein SLX9 homolog (SLX9).	[3]
Epigallocatechin gallate	DMCGWBJ	Phase 3	Epigallocatechin gallate decreases the expression of Ribosome biogenesis protein SLX9 homolog (SLX9).	[4]
Milchsaure	DM462BT	Investigative	Milchsaure decreases the expression of Ribosome biogenesis protein SLX9 homolog (SLX9).	[8]

References

• [1] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [2] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [3] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [4] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [5] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [6] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [7] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [8] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.