Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQA2GZO)

DOT Name Carnosine N-methyltransferase (CARNMT1)
Synonyms EC 2.1.1.22
Gene Name CARNMT1
UniProt ID
CARME_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
5YF0; 5YF1; 5YF2
EC Number
2.1.1.22
Pfam ID
PF07942
Sequence
MQRRRRPPPPTSRLPEGCGGGGGGSEEVEVQFSAGRWGSAAAVSAAAAAATRSTEEEEER
LEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFLLHLDKIRKCIDHNQ
EILLTIVNDCIHMFENKEYGEDGNGKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDAC
YQPIIKEILKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSFFMLFSSNF
VLNRCSEINKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIY
SECNTWDCIATCFFIDTAHNVIDYIDTIWKILKPGGIWINLGPLLYHFENLANELSIELS
YEDIKNVVLQYGFKVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ
Function
N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).
Tissue Specificity Expressed at higher level in kidney. Expressed at lower level in brain and skeletal muscle.
KEGG Pathway
Histidine metabolism (hsa00340 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Histidine catabolism (R-HSA-70921 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
7 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Acetaminophen decreases the expression of Carnosine N-methyltransferase (CARNMT1). [1]
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of Carnosine N-methyltransferase (CARNMT1). [2]
Estradiol DMUNTE3 Approved Estradiol increases the expression of Carnosine N-methyltransferase (CARNMT1). [3]
Quercetin DM3NC4M Approved Quercetin decreases the expression of Carnosine N-methyltransferase (CARNMT1). [4]
Urethane DM7NSI0 Phase 4 Urethane decreases the expression of Carnosine N-methyltransferase (CARNMT1). [5]
Formaldehyde DM7Q6M0 Investigative Formaldehyde decreases the expression of Carnosine N-methyltransferase (CARNMT1). [6]
OXYQUINOLINE DMZVS9Y Investigative OXYQUINOLINE decreases the expression of Carnosine N-methyltransferase (CARNMT1). [4]
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⏷ Show the Full List of 7 Drug(s)

References

1 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
2 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
3 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
4 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
5 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
6 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.