Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQCIZOD)

DOT Name	Beta-hexosaminidase (nag1)
Synonyms	EC 3.2.1.52
Gene Name	nag1
UniProt ID	P87258_TRIHA
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	3.2.1.52
Pfam ID	PF00728 ; PF14845
Sequence	MLPKASLAIAALAFSPANALWPIPQKITTGDSVLFIDEAVRVTYNGVPIITIGYNPPAGS NFNSKEIVQGAVSRTFQSIFTNNFVPWKLNPRNSNFEPKLAPLNRIQTIAIQQTGKDTAT TFKPRAGDVDESYSLTVSKNGQVNISAKTSTGILHALETFSQLFYQHSAGHYFYTTQVPV SIQDSPNYPHRGVMLDLARTYQTVADIKRTIDAMSWNKLNRLHLHITDSQSWPLVIPSLP KLSQEGAYHPSLVYSPADLAGIFQYGIDRGVEVITEIDMPGHIGVVELAYSDLIVAYQEM PYQYYCAEPPCGAFSFNDSKVYDFVDKLFDDLLPRVTPYSSYFHTGGDELNANDSMIDPR YKSNSSDVLQPLLQKFISHAHSKIRAQGLSPLVCEEMVTTWNLTLGSDTVVQSWLGGDAV KNLAESGYKVIDTDYNFYYLDCGRGQWVNFPNGDSFNTYYPFSDWCAPTKNWRLIYSHDP AKGVSKANAKNVLGGELAIWSEMIDGSNMDNIIWPRGSAAGEVWWSGNVDTATGQNRSQL EVTPRLNEFRERMLARGVNAMPIQMTYCTQLNATACTLFA

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Tobramycin	DMUI0CH	Approved	Beta-hexosaminidase (nag1) increases the Nephropathy toxic ADR of Tobramycin.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.