Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQOYX6U)

• DOT Name: Speedy protein E1 (SPDYE1)
• Synonyms: Williams-Beuren syndrome chromosomal region 19 protein
• Gene Name: SPDYE1
• UniProt ID: SPDE1_HUMAN
• Pfam ID: PF11357
• Sequence:
  MQKHYTVAWFLYSAPGVDPSPPCRSLGWKRKREWSDESEEEPEKELAPEPEETWVVETLC
  GLKMKLKQQRVSPILLEHHKDFNSQLAPGVDPSPPHRSFCWKRKMEWWDKSEESEEEPRK
  VLAPEPEEIWVAEMLCGLKMKLKRRRVSLVLPEHHEAFNRLLEDPVIKRFLAWDKDLRVS
  DKYLLAMVIAYFSRAGFPSWQYQRLHFFLALYLANDMEEDDEDSKQNIFHFLYGKNRSRI
  PLLRKRRFQLYRSMNPRARKNRSHIPLVRKRRFQLRRCMNPRARKNRSQIVLFQKRRFHF
  FCSMSCRAWVSPEELEEIQAYDPEHWVWARDRARLS
• Tissue Specificity: Predominantly expressed in testis and heart.
• KEGG Pathway:
  Oocyte meiosis (hsa04114)
  Progesterone-mediated oocyte maturation (hsa04914)

Molecular Interaction Atlas (MIA) of This DOT

4 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Zoledronate	DMIXC7G	Approved	Zoledronate increases the expression of Speedy protein E1 (SPDYE1).	[1]
Formaldehyde	DM7Q6M0	Investigative	Formaldehyde increases the expression of Speedy protein E1 (SPDYE1).	[2]
Milchsaure	DM462BT	Investigative	Milchsaure increases the expression of Speedy protein E1 (SPDYE1).	[3]
KOJIC ACID	DMP84CS	Investigative	KOJIC ACID increases the expression of Speedy protein E1 (SPDYE1).	[4]

References

• [1] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [2] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [3] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [4] Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.