Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTRU5QPO)

• DOT Name: Ribosome biogenesis protein NSA2 homolog (NSA2)
• Synonyms: Hairy cell leukemia protein 1; TGF-beta-inducible nuclear protein 1
• Gene Name: NSA2
• Related Disease:
  Diabetic kidney disease
  Hyperglycemia
  Type-1/2 diabetes
  Hairy cell leukaemia
  Neoplasm
  Primary biliary cholangitis
  Nephropathy
  Non-insulin dependent diabetes
• UniProt ID: NSA2_HUMAN
• PDB ID: 8FKR; 8FKS; 8FKT; 8FKU; 8FKV; 8FKW; 8FKX; 8FKY; 8FKZ; 8FL0; 8FL2; 8FL3; 8FL4; 8FL6; 8FL7; 8FL9; 8IDY; 8IE3; 8INE; 8INF; 8INK; 8IPD; 8IPX; 8IPY; 8IR1; 8IR3
• Pfam ID: PF01201
• Sequence:
  MPQNEYIELHRKRYGYRLDYHEKKRKKESREAHERSKKAKKMIGLKAKLYHKQRHAEKIQ
  MKKTIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRAKVLSNMIKQKRKEKAGKWEVP
  LPKVRAQGETEVLKVIRTGKRKKKAWKRMVTKVCFVGDGFTRKPPKYERFIRPMGLRFKK
  AHVTHPELKATFCLPILGVKKNPSSPLYTTLGVITKGTVIEVNVSELGLVTQGGKVIWGK
  YAQVTNNPENDGCINAVLLV
• Function: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.

Molecular Interaction Atlas (MIA) of This DOT

8 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Diabetic kidney disease	DISJMWEY	Definitive	Biomarker	[1]
Hyperglycemia	DIS0BZB5	Definitive	Biomarker	[1]
Type-1/2 diabetes	DISIUHAP	Definitive	Biomarker	[1]
Hairy cell leukaemia	DISTD2E5	Strong	Biomarker	[2]
Neoplasm	DISZKGEW	Strong	Altered Expression	[2]
Primary biliary cholangitis	DIS43E0O	Strong	Biomarker	[3]
Nephropathy	DISXWP4P	Limited	Altered Expression	[4]
Non-insulin dependent diabetes	DISK1O5Z	Limited	Biomarker	[4]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene decreases the methylation of Ribosome biogenesis protein NSA2 homolog (NSA2).	[5]
PMID28870136-Compound-52	DMFDERP	Patented	PMID28870136-Compound-52 decreases the phosphorylation of Ribosome biogenesis protein NSA2 homolog (NSA2).	[6]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
chloropicrin	DMSGBQA	Investigative	chloropicrin affects the expression of Ribosome biogenesis protein NSA2 homolog (NSA2).	[7]

References

• [1] Nop-7-associated 2 (NSA2), a candidate gene for diabetic nephropathy, is involved in the TGF1 pathway.Int J Biochem Cell Biol. 2013 Mar;45(3):626-35. doi: 10.1016/j.biocel.2012.11.020. Epub 2012 Dec 7.
• [2] A novel human TINP1 gene promotes cell proliferation through inhibition of p53 and p21 expression.Oncol Rep. 2013 Oct;30(4):1848-52. doi: 10.3892/or.2013.2647. Epub 2013 Aug 1.
• [3] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [4] Elevated levels of renal and circulating Nop-7-associated 2 (NSA2) in rat and mouse models of diabetes, in mesangial cells in vitro and in patients with diabetic nephropathy.Diabetologia. 2012 Mar;55(3):825-34. doi: 10.1007/s00125-011-2373-4. Epub 2011 Nov 18.
• [5] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [6] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [7] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.