Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTRZVDSE)

DOT Name BPI fold-containing family B member 6 (BPIFB6)
Synonyms Bactericidal/permeability-increasing protein-like 3
Gene Name BPIFB6
Related Disease
Rectal carcinoma ( )
UniProt ID
BPIB6_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF01273 ; PF02886
Sequence
MLRILCLALCSLLTGTRADPGALLRLGMDIMNQVQSAMDESHILEKMAAEAGKKQPGMKP
IKGITNLKVKDVQLPVITLNFVPGVGIFQCVSTGMTVTGKSFMGGNMEIIVALNITATNR
LLRDEETGLPVFKSEGCEVILVNVKTNLPSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAV
LVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPVVQQQKGKTIKLADAG
EALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQDTMIGELPPQTTKTLARFIPE
VAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHF
NLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPVVNDVL
QVGLPLPDFLAMNYNLAELDIVENALMLDLKLG
Tissue Specificity Detected at very low levels in normal tonsils, and at higher levels in hypertrophic tonsils.
Reactome Pathway
Antimicrobial peptides (R-HSA-6803157 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Rectal carcinoma DIS8FRR7 Limited Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Formaldehyde DM7Q6M0 Investigative Formaldehyde decreases the expression of BPI fold-containing family B member 6 (BPIFB6). [2]
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References

1 Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature.Epigenomics. 2016 Sep;8(9):1193-207. doi: 10.2217/epi-2016-0044. Epub 2016 Aug 16.
2 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.