Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTSO833D)

DOT Name Lipase member I (LIPI)
Synonyms LIPI; EC 3.1.1.-; Cancer/testis antigen 17; CT17; LPD lipase; Membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta
Gene Name LIPI
Related Disease
Ewing sarcoma/peripheral primitive neuroectodermal tumor ( )
Neoplasm ( )
Hypertriglyceridemia ( )
UniProt ID
LIPI_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
EC Number
3.1.1.-
Pfam ID
PF00151
Sequence
MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLF
EQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTF
IYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRIT
GLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPK
SIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRL
GYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLL
NQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQ
SLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPKNT
Function
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Tissue Specificity Expressed in testis. Expressed exclusively at the connecting piece of the sperm.
Reactome Pathway
Synthesis of PA (R-HSA-1483166 )

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Ewing sarcoma/peripheral primitive neuroectodermal tumor DISD4VQC Strong Biomarker [1]
Neoplasm DISZKGEW Strong Biomarker [2]
Hypertriglyceridemia DIS7SN6U Limited Autosomal dominant [3]
------------------------------------------------------------------------------------
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Lipase member I (LIPI). [4]
------------------------------------------------------------------------------------

References

1 Characterization of Ewing sarcoma associated cancer/testis antigens.Cancer Biol Ther. 2013 Mar;14(3):254-61. doi: 10.4161/cbt.23298. Epub 2013 Jan 4.
2 Identification of cancer/testis genes by database mining and mRNA expression analysis.Int J Cancer. 2002 Apr 1;98(4):485-92. doi: 10.1002/ijc.10276.
3 The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
4 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.