Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTTU3FKC)

DOT Name	Mitochondrial substrate carrier family protein ancA (ancA?)
Synonyms	ADP,ATP carrier protein; ADP/ATP translocase; Adenine nucleotide translocator; ANT
Gene Name	ancA?
UniProt ID	ADT_DICDI
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00153
Sequence	MSNQKKNDVSSFVKDSLIGGTAGGVSKTIVAPIERVKLLLQVQSASTQIAADKQYKGIVD CFVRVSKEQGVISLWRGNLANVIRYFPTQALNFAFKDKYKKFFVRHTAKENPTKFFIGNL LSGGAAGATSLLFVYPLDFARTRLAADVGTGSARQFTGLGNCISSIYKRDGLIGLYRGFG VSVGGIFVYRAAFFGGYDTAKGILLGENNKKASFWASWGIAQVVTTIAGVVSYPFDTVRR RMMMQAGRADILYSSTWDCWVKIATREGPTAFFKGALSNAIRGSGGALVLVIYDEIQKLM GFEGGVGSE
Function	ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.
Reactome Pathway	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (R-DDI-83936 ) Mitochondrial protein import (R-DDI-1268020 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Propylthiouracil	DM6D7N8	Approved	Mitochondrial substrate carrier family protein ancA (ancA?) increases the Vasculitis ADR of Propylthiouracil.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.