Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTUASJZK)

DOT Name Putative spermatogenesis-associated protein 31C1 (SPATA31C1)
Synonyms Protein FAM75C1
Gene Name SPATA31C1
UniProt ID
S31C1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF15371 ; PF14650
Sequence
MENLPFPLKLLSASSLNTPSSTPWVLDIFLTLVFALGLFFLLLPYFSYLRCDNPPSPSPR
KRKRHLVSQRHLVSQCPTGRRGRPRGRMKNHSLRACRECPRGLEETWDLLSQLQSLLGPH
LEKGDFGQLSGPDPPGEVGKRTPDGASRSSHEPMEDAAPIVSPLASPDPRTKHPQDLAST
PPPGPMTTSVSSLSASQPPEPSLLLERPSPEPPALFPHPPHTPDPLACSPPPPKGFTPPP
LRDSTLLTPSHCDSVALPLDTVPQSLSPREDLAASVPAISGLGGSNSQVSALSWSQETTK
TWCIFNSSVQQDHLSRQRDTTMSPLLFQAQPLSHLGPESQPFISSTPQFRPTPMAQAEAQ
AHLQSSFPVLSPAFLSPMKNTGVACPASQNKVQALSLPETQHPERPLLRKQLEGGLALPS
RVQKSQDVFSVSTPNLPQERLTSILPENFPVSPELWRQLEQYMGQRGRIQESLDLMQLQD
ELPGTSQAKGKPRPWQSSTSTGESSKEAQTVKFQLERDPCPHLGQILGETPQNLSRGMES
FPGKVLGATSEESERNLRKPLRSDSGSDLLRRTERNHIENILKAHMGRKLGQTNEGLIPV
SVRRSWLAVNQAFPVSNTHVKTSNLAAPKSRKACVNTAQVLSFLELCTQQVLEAHIVRFW
AKHRWGLPLRVLKPIQCFQLEKVSSLSLIQLAGPSSDTCESGAGSKVEVATLLGEPPMAS
LRKQVLTKPSVHMPERLQASSPACKQFQRAPRGIPSSNDHGSLKAPTAGQEGRWPSKPLT
YSLKGSTQQSRSLGAQSSRAGETREAVPQPTVPLGTCMRANLQATSEDVRGFKAPGASKS
SLLPRMSVSQDPRKLCLMEEAVSEFEPGMATKSETQPQVSAAVVLLPDGQASVVPHASEN
LASQVPQGHLQSTPTGNMQASQELCDLMSARRSNMGHKEPRNPNCQGSCKSQSPMFPPTH
KRENSRKPNLEKHEEMFQGLRTPQLTPGRKTEDTRQNEGVQLLPSKKQPPSISHFGENIK
QFFETIFSKKERKPAPVTAESQKTVKNRSCVYGSSAEAERLMTAVGQIPEENMSLCHARH
ASKVNQQRQQFQAPVCGFPCNHRHPFYSDHSRMLSYAASSQQATLKNQSRPNRDRQIRDQ
QPLKSVRCNNEQWGLRHPQLLLPKKAVSPVSPPQHRPKTPSASSHHHH
Function May play a role in spermatogenesis.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Putative spermatogenesis-associated protein 31C1 (SPATA31C1). [1]
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1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Putative spermatogenesis-associated protein 31C1 (SPATA31C1). [2]
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References

1 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
2 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.