Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTUEJ1MR)

• DOT Name: Uncharacterized protein C1orf167 (C1ORF167)
• Gene Name: C1ORF167
• Related Disease: Schizophrenia
• UniProt ID: CA167_HUMAN
• Pfam ID: PF15736
• Sequence:
  MELRSDASHKENVSPKPAALPKPEQRRFRRSLGIGLSGRHDQWVPGCQVERGGPAATPSP
  GAVLDQEPCRVQTNLASPGPRLGLALKDTTGQLVNSSFWQQSNLQSLARRRQGKAREFAI
  QQSNLSINETSSPHLCPEPGGSSGPHKLPWGPLLSQEPLARPSSCLRQSGLPAPGTPSGD
  FRPTEAFAPLDGHTQPGLRSWGGLGSWRSRLVGEPLTLEDLAVPSQNQTQAPSRAAVHQL
  LASVHCLAQEAARLRCQAPQEPPGAVQQDLWTGGGQPFSAHPQPSQPVLASSDGRRRRLR
  GHRETAAFLETPASLSDSWAQSKLMSPETTLGTRTKDSLNPEQGLPPAHPLGSGDSCSPW
  SQDGRAQRGDPSLPRGVGSRGTDPCSSAFSNTAWGVSPKQKGEEGAPRERVHREEERTAF
  HLSDTVPASSASKNKAQNITAPESEAICWQLLSRCFRSWRHLVKRQREPAAAAVALGRWQ
  LLRKCLQALWLREAQLEAAWGQYTKVLLVRSFREWRNLALQQKQVQPHMQAGPGSPPSRR
  AQGKGLSLGRSTVVDPAQRSRLEHTSPGSLREEEIAQRLLSHPRQRTDSRHERVQILQAL
  QLAVFFLWCQQKKRARQERETLRKATRATQRTGSFPQAWHSTAAGVAWVAPLSPQHQRAW
  LCRCFGAWQQFVQRGSRYRDHLADRRTGTLRKCLEQWVRMKQLRESDGAKVTQLSLCRQK
  AGREAVYTAGPGACGLGAVGQAQGQQEQGRGSLQDACWTLALCWALLLWKMRLFQRQWAN
  SFFQGLQQRMLQRSLRWWHLRALGPDATSSCTKTPSALEPLSSSTLQDSLEKVPRAPTLP
  DTLQGSLLWAAGQRQQGQCLLLWQARAQQFQGTARWYQHTRQRRIFLSWSRWATAQWAWR
  ELASHRAWDRTCRAVLGLWRQRLLQSRLVEWWAQERGWRLARDALCHWHSCWQGQQFLHE
  KCQTWVQVHLQGLQKVVFRSWQQAAAHQRCTVTRPEQLLLQSYFQAWCEVVRDTGVLRAQ
  HQAFQDGLRRRALGAVFATWREAQEVAAGAQEQRVAQASLARWRSCGQQGQEDGQQKKAR
  APQAFPAWPVAPGMHHEAQQQAGESAGAQAAQCWTWCWALWVHESCRGQVSRAHASWKPR
  AWVLEASVQSAVRGGVQRAILTQLRPAELRRFLRTVQLRVRLGLPGAGKTRSCWTQATEL
  VPPAPSLQCSLGGRRKPRGTAWAQRCREHSLCPAFQLWPQWPGQSSWVPGLPLWTRDQGP
  RAHSSPEPRACKAQSKAHKRRLRARSCRILEKQAQAHGSALLLALKGHDALGHQEEVPAA
  PVPRGTASRAAGFPAGQVPGSGMAALGGCPRGRAAGADPAQGVAPEMGLADVVAADPATA
  SGSAVTAAGRWAFKKWHQRLAARSPRRGAASSPRPWSKPGPKGPESGQEAARAPRGWGLG
  AEHGAQLQL

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Schizophrenia	DISSRV2N	Strong	Genetic Variation	[1]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the methylation of Uncharacterized protein C1orf167 (C1ORF167).	[2]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A increases the expression of Uncharacterized protein C1orf167 (C1ORF167).	[3]

References

• [1] Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population.Mol Psychiatry. 2017 Jul;22(7):954-960. doi: 10.1038/mp.2016.212. Epub 2016 Dec 6.
• [2] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [3] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.