Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTUPKABF)

• DOT Name: Blood group Rh(D) polypeptide (RHD)
• Synonyms: RHXIII; Rh polypeptide 2; RhPII; Rhesus D antigen; CD antigen CD240D
• Gene Name: RHD
• Related Disease: Rh deficiency syndrome
• UniProt ID: RHD_HUMAN
• Pfam ID: PF00909
• Sequence:
  MSSKYPRSVRRCLPLWALTLEAALILLFYFFTHYDASLEDQKGLVASYQVGQDLTVMAAI
  GLGFLTSSFRRHSWSSVAFNLFMLALGVQWAILLDGFLSQFPSGKVVITLFSIRLATMSA
  LSVLISVDAVLGKVNLAQLVVMVLVEVTALGNLRMVISNIFNTDYHMNMMHIYVFAAYFG
  LSVAWCLPKPLPEGTEDKDQTATIPSLSAMLGALFLWMFWPSFNSALLRSPIERKNAVFN
  TYYAVAVSVVTAISGSSLAHPQGKISKTYVHSAVLAGGVAVGTSCHLIPSPWLAMVLGLV
  AGLISVGGAKYLPGCCNRVLGIPHSSIMGYNFSLLGLLGEIIYIVLLVLDTVGAGNGMIG
  FQVLLSIGELSLAIVIALMSGLLTGLLLNLKIWKAPHEAKYFDDQVFWKFPHLAVGF
• Function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
• Tissue Specificity: Restricted to tissues or cell lines expressing erythroid characters.
• Reactome Pathway: Rhesus blood group biosynthesis (R-HSA-9037628)

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Rh deficiency syndrome	DISW2W1R	Supportive	Autosomal recessive	[1]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Amphotericin B	DMTAJQE	Approved	Amphotericin B increases the expression of Blood group Rh(D) polypeptide (RHD).	[2]

References

• [1] Rhnull disease: the amorph type results from a novel double mutation in RhCe gene on D-negative background. Blood. 1998 Jul 15;92(2):664-71.
• [2] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.