Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTUZZ67L)

DOT Name	Heat shock protein beta-1 (HSPB1)
Synonyms	HspB1; 25 kDa IAP; Actin polymerization inhibitor; Heat shock 25 kDa protein; HSP 25; Heat shock 27 kDa protein; HSP 27
Gene Name	HSPB1
UniProt ID	HSPB1_CHICK
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00011
Sequence	MAERRVPFTFLTSPSWEPFRDWYHGSRLFDQSFGMPHIPEDWYKWPSGSAWPGYFRLLPS ESALLPAPGSPYGRALSELSSGISEIRQSADSWKVTLDVNHFAPEELVVKTKDNIVEITG KHEEKQDEHGFISRCFTRKYTLPPGVEATAVRSSLSPDGMLTVEAPLPKPAIQSSEITIP VTVEAKKEEPAKK
Function	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization.
Tissue Specificity	Smooth, cardiac and skeletal muscle, hardly detectable in fibroblasts or focal contacts.

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 1 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Arsenic trioxide	DM61TA4	Approved	Heat shock protein beta-1 (HSPB1) increases the Necrotising enterocolitis neonatal ADR of Arsenic trioxide.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.