Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTV8IASE)

DOT Name 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13)
Synonyms 17-beta-HSD 13; EC 1.1.1.-; EC 1.1.1.62; Hepatic retinol/retinal dehydrogenase; EC 1.1.1.105; Short chain dehydrogenase/reductase family 16C member 3; Short-chain dehydrogenase/reductase 9
Gene Name HSD17B13
UniProt ID
DHB13_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
8G9V
EC Number
1.1.1.-; 1.1.1.105; 1.1.1.62
Pfam ID
PF00106
Sequence
MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ
SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN
AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP
YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD
EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
Function
Plays a pivotal role in hepatic lipid metabolism. In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 ; [Isoform 2]: Has retinol/retinal dehydrogenase activity in vitro; [Isoform 1]: Does not have retinol/retinal dehydrogenase activity in vitro.
Tissue Specificity Highly expressed in the liver . Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.
Reactome Pathway
Lipid particle organization (R-HSA-8964572 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Troglitazone DM3VFPD Approved Troglitazone decreases the expression of 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13). [1]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the methylation of 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13). [2]
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References

1 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
2 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.