Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVOJU6G)

DOT Name ATP-dependent RNA helicase DDX54 (DDX54)
Synonyms EC 3.6.4.13; ATP-dependent RNA helicase DP97; DEAD box RNA helicase 97 kDa; DEAD box protein 54
Gene Name DDX54
Related Disease
Breast cancer ( )
Breast carcinoma ( )
Liver cancer ( )
Polycystic ovarian syndrome ( )
Precancerous condition ( )
UniProt ID
DDX54_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
8FKT; 8FKU; 8FKV; 8FKW; 8FKX; 8FKY
EC Number
3.6.4.13
Pfam ID
PF08147 ; PF00270 ; PF00271
Sequence
MAADKGPAAGPRSRAAMAQWRKKKGLRKRRGAASQARGSDSEDGEFEIQAEDDARARKLG
PGRPLPTFPTSECTSDVEPDTREMVRAQNKKKKKSGGFQSMGLSYPVFKGIMKKGYKVPT
PIQRKTIPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGARALILSPTRELAL
QTLKFTKELGKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLVHVAVEMSLKLQS
VEYVVFDEADRLFEMGFAEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIR
LDVDTKLNEQLKTSFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTT
QRVSCAHIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGK
LFLHRVGRVARAGRSGTAYSLVAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGML
GRVPQSVVDEEDSGLQSTLEASLELRGLARVADNAQQQYVRSRPAPSPESIKRAKEMDLV
GLGLHPLFSSRFEEEELQRLRLVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQKDRKA
IARFQQGQQGRQEQQEGPVGPAPSRPALQEKQPEKEEEEEAGESVEDIFSEVVGRKRQRS
GPNRGAKRRREEARQRDQEFYIPYRPKDFDSERGLSISGEGGAFEQQAAGAVLDLMGDEA
QNLTRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESGRYISSSYKRDLYQKWKQKQKIDDR
DSDEEGASDRRGPERRGGKRDRGQGASRPHAPGTPAGRVRPELKTKQQILKQRRRAQKLH
FLQRGGLKQLSARNRRRVQELQQGAFGRGARSKKGKMRKRM
Function Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.
Tissue Specificity Expressed in the fallopian tube, cervix and uterus. Also expressed in the brain.

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Breast cancer DIS7DPX1 Strong Biomarker [1]
Breast carcinoma DIS2UE88 Strong Biomarker [1]
Liver cancer DISDE4BI Strong Biomarker [2]
Polycystic ovarian syndrome DISZ2BNG Strong Biomarker [3]
Precancerous condition DISV06FL Strong Biomarker [2]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
4 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of ATP-dependent RNA helicase DDX54 (DDX54). [4]
Quercetin DM3NC4M Approved Quercetin increases the phosphorylation of ATP-dependent RNA helicase DDX54 (DDX54). [7]
PMID28870136-Compound-52 DMFDERP Patented PMID28870136-Compound-52 affects the phosphorylation of ATP-dependent RNA helicase DDX54 (DDX54). [7]
Coumarin DM0N8ZM Investigative Coumarin increases the phosphorylation of ATP-dependent RNA helicase DDX54 (DDX54). [7]
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3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Doxorubicin DMVP5YE Approved Doxorubicin decreases the expression of ATP-dependent RNA helicase DDX54 (DDX54). [5]
Estradiol DMUNTE3 Approved Estradiol increases the expression of ATP-dependent RNA helicase DDX54 (DDX54). [6]
APR-246 DMNFADH Phase 2 APR-246 affects the expression of ATP-dependent RNA helicase DDX54 (DDX54). [8]
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References

1 Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97).J Biol Chem. 2003 Feb 14;278(7):4628-38. doi: 10.1074/jbc.M210066200. Epub 2002 Dec 3.
2 Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.Toxicol Sci. 2009 Apr;108(2):273-89. doi: 10.1093/toxsci/kfp031. Epub 2009 Feb 20.
3 Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.J Clin Endocrinol Metab. 2011 Jun;96(6):1737-46. doi: 10.1210/jc.2010-2600. Epub 2011 Mar 16.
4 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
5 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
6 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
7 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
8 Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.