Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTVUH7KR)

DOT Name Serine protease 58 (PRSS58)
Synonyms EC 3.4.21.4; Trypsin-X3
Gene Name PRSS58
Related Disease
Hereditary chronic pancreatitis ( )
Pancreatitis ( )
Colonic neoplasm ( )
UniProt ID
PRS58_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
3.4.21.4
Pfam ID
PF00089
Sequence
MKFILLWALLNLTVALAFNPDYTVSSTPPYLVYLKSDYLPCAGVLIHPLWVITAAHCNLP
KLRVILGVTIPADSNEKHLQVIGYEKMIHHPHFSVTSIDHDIMLIKLKTEAELNDYVKLA
NLPYQTISENTMCSVSTWSYNVCDIYKEPDSLQTVNISVISKPQCRDAYKTYNITENMLC
VGIVPGRRQPCKEVSAAPAICNGMLQGILSFADGCVLRADVGIYAKIFYYIPWIENVIQN
N

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Hereditary chronic pancreatitis DISF0J1Q Strong Genetic Variation [1]
Pancreatitis DIS0IJEF Strong Genetic Variation [2]
Colonic neoplasm DISSZ04P Limited Altered Expression [3]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
2 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the methylation of Serine protease 58 (PRSS58). [4]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Serine protease 58 (PRSS58). [5]
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References

1 Cationic trypsinogen mutations and pancreatitis.Clin Lab Med. 2005 Mar;25(1):39-59. doi: 10.1016/j.cll.2004.12.004.
2 Metastatic pancreatic adenocarcinoma associated with chronic calcific pancreatitis and a heterozygous SPINK1 N34S mutation.Pancreatology. 2016 Sep-Oct;16(5):869-72. doi: 10.1016/j.pan.2016.06.006. Epub 2016 Jun 21.
3 Human trypsinogen in colorectal cancer.Int J Cancer. 2001 Jul 1;93(1):67-73. doi: 10.1002/ijc.1304.
4 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
5 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.