Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTWM7KSJ)

• DOT Name: cTAGE family member 2 (CTAGE1)
• Synonyms: Protein cTAGE-2; Cancer/testis antigen 21.2; CT21.2
• Gene Name: CTAGE1
• Related Disease:
  Advanced cancer
  Colon carcinoma
  Melanoma
  Primary cutaneous T-cell lymphoma
  Tarsal-carpal coalition syndrome
  Neoplasm
• UniProt ID: CTGE2_HUMAN
• Sequence:
  MRPDSHPYGFPWELVIRAAVAGFFAVLFLWRSFRSVTSRLYVRREKKFAVALSGLIEEKC
  KLLEKFSLVQKEYEGYEVESSLKNASFEKEATEAQSLEATCEKLNRFNSELVHEILCLEK
  ELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEAKMTFKRFQANEERLEIEIQD
  AWKENSELQESQKQLLQEAEVWKEQVSELIKQKRTFEDSKVHAEQVLNDKENHIKTLTER
  LLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLDNPPKGALKKLIHAAKLNASLKTLE
  GERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFESENQKLQQKLKVMTELYQ
  ENEMKLYRKLIVEEKCRLEKEEKLSKVDEMISHATEELETYRKRAKDLKEFEKTIHFYQK
  KIILHEKKAHDNWSAAWTAERNLNDLRKENAHNRQKLTEIEFKIKLLEKDPYGLDVPNTA
  FGRQHSPYGPSPLGWPSSETRASLYPPTLLEGPLRLSPLLPRGGGRGSRGPGNPPDHQIT
  KERGESSCDRLTDPHRAPSDAGPLAPPWEQDYRMMFPPPGQSYPDSALPPQRQDRFYSNC
  ARLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDNLGNLKVPDSSLPAENEATGPGF
  VPPPLAPIRGLLFPVDTRGPFIRRGPPFPPPPPGTVFGASPDYFSPRDVPGPPRAPFAMR
  NVYLPRGFLPYRPPRPAFFPPAPTF
• Tissue Specificity: Testis. Not found in tumor.

Molecular Interaction Atlas (MIA) of This DOT

6 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Advanced cancer	DISAT1Z9	Strong	Biomarker	[1]
Colon carcinoma	DISJYKUO	Strong	Biomarker	[1]
Melanoma	DIS1RRCY	Strong	Genetic Variation	[1]
Primary cutaneous T-cell lymphoma	DIS35WVW	Strong	Altered Expression	[2]
Tarsal-carpal coalition syndrome	DISY90L2	Strong	Genetic Variation	[3]
Neoplasm	DISZKGEW	Limited	Biomarker	[4]

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Folic acid	DMEMBJC	Approved	Folic acid decreases the expression of cTAGE family member 2 (CTAGE1).	[5]

1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of cTAGE family member 2 (CTAGE1).	[6]

References

• [1] cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing.J Invest Dermatol. 2003 Jul;121(1):198-206. doi: 10.1046/j.1523-1747.2003.12318.x.
• [2] Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.Clin Cancer Res. 2014 Jul 15;20(14):3799-808. doi: 10.1158/1078-0432.CCR-14-0307. Epub 2014 May 21.
• [3] Expression profile of cancer-testis genes in transitional cell carcinoma of the bladder.Urol Oncol. 2012 Nov-Dec;30(6):886-92. doi: 10.1016/j.urolonc.2010.08.017. Epub 2011 Mar 10.
• [4] Serological detection of cutaneous T-cell lymphoma-associated antigens.Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):629-34. doi: 10.1073/pnas.98.2.629. Epub 2001 Jan 9.
• [5] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [6] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.