Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTWXSQNG)

DOT Name	Small integral membrane protein 23 (SMIM23)
Gene Name	SMIM23
UniProt ID	SIM23_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF15466
Sequence	MATQQVDSRRQVAAEQVAAQLLERRRGSHCDDEKQTLLALLILVLYLSTEIWGSSWEVSE RIRECNYYQNLAVPQGLEYQTNEPSEEPIKTIRNWLKEKLHVFSEKLEEEVQQLEQLAWD LELWLDALLGEPHQEEHCSTYKSHLWEWAWALGREHKGGEGLLEISLSGAEL

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Acetaminophen	DMUIE76	Approved	Acetaminophen decreases the expression of Small integral membrane protein 23 (SMIM23).	[1]
------------------------------------------------------------------------------------

References

1	Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.