Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTX1DYWW)

DOT Name Chymase (CMA1)
Synonyms EC 3.4.21.39; Alpha-chymase; Mast cell protease I
Gene Name CMA1
UniProt ID
CMA1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1KLT; 1NN6; 1PJP; 1T31; 2HVX; 3N7O; 3S0N; 4AFQ; 4AFS; 4AFU; 4AFZ; 4AG1; 4AG2; 4K2Y; 4K5Z; 4K60; 4K69; 4KP0; 5YJM; 5YJP
EC Number
3.4.21.39
Pfam ID
PF00089
Sequence
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
Function Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Tissue Specificity Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions.
KEGG Pathway
Renin-angiotensin system (hsa04614 )
Diabetic cardiomyopathy (hsa05415 )
Reactome Pathway
Activation of Matrix Metalloproteinases (R-HSA-1592389 )
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377 )
Signaling by SCF-KIT (R-HSA-1433557 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Malathion DMXZ84M Approved Malathion decreases the expression of Chymase (CMA1). [1]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene decreases the expression of Chymase (CMA1). [2]
Paraquat DMR8O3X Investigative Paraquat increases the expression of Chymase (CMA1). [3]
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References

1 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
2 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
3 Chymase mediates paraquat-induced collagen production in human lung fibroblasts. Toxicol Lett. 2010 Mar 1;193(1):19-25. doi: 10.1016/j.toxlet.2009.12.001. Epub 2009 Dec 5.