Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTXIP28J)

DOT Name Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
Synonyms PHK-gamma-M; EC 2.7.11.19; Phosphorylase kinase subunit gamma-1; Serine/threonine-protein kinase PHKG1; EC 2.7.11.1, EC 2.7.11.26
Gene Name PHKG1
UniProt ID
PHKG1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
2.7.11.1; 2.7.11.19; 2.7.11.26
Pfam ID
PF12330 ; PF00069
Sequence
MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS
PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV
TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER
LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR
MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS
PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK
KGQQQNRAALFENTPKAVLLSLAEEDY
Function
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.
KEGG Pathway
Calcium sig.ling pathway (hsa04020 )
Insulin sig.ling pathway (hsa04910 )
Glucagon sig.ling pathway (hsa04922 )
Reactome Pathway
Glycogen breakdown (glycogenolysis) (R-HSA-70221 )
BioCyc Pathway
MetaCyc:HS09136-MONOMER

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Epanova DMHEAGL Approved Epanova increases the expression of Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1). [1]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1). [2]
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References

1 Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
2 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.