Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTYJDOLG)

DOT Name Beta-N-acetylglucosaminidase (lytD)
Synonyms EC 3.2.1.96; Cell wall-associated polypeptide 90; CWBP90
Gene Name lytD
UniProt ID
LYTD_BACSU
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
3.2.1.96
Pfam ID
PF01832 ; PF08239 ; PF05036
Sequence
MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTFSTESQASQAVAKLEKD
TGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSITGTSSPVGSKQPYVTISS
GAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMTSDIADETKVKALIQSLAKQT
GIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQKESGLQASLKETVKGQAYYTFTT
AAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVESYNVQSAYFKGLSTVKDAISQIKK
NTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDTFFKKKKWHYTSSSVKKTTTSAAYQIT
TAKILGEQQANKAAAFFAQKKVKAAKTAAGSTAENQYQLISEETSDQAKVTKGLNILKKN
QLSASAKSVKKQIADTFKITTESLLDQTKVNQALTFFKSNHISVASQKTGQTAASSYQIT
TEAIISQEEIDRVLTFFKQNHIAVTTSKTGQTAYTQYKIVTTQLSSKTALNNGLTYLKSK
SVTPSYTTKSNTLYKISVNEQFTGNDTAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYN
LSLRDMVQKQMTVSPQTDGAAYVSLTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKG
DKVKVIGQINGWAKINLGWRNASSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEV
NQKVLAGKGILTGRAKAFIDAANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYN
MYGIGAYDSNPNYYGAKYAYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSA
TATHQYATDIGWAYKQVNRMYSLYSLLDGYTLYFDVPEYR
Function
Cell wall hydrolase not involved in cell autolysis, competence, sporulation or germination. It hydrolyzes the beta-1,4 glycan bond between the N-acetylglucosaminyl and the N-acetylmuramoyl residues in the glycan chain.
BioCyc Pathway
BSUB:BSU35780-MONOMER

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 1 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Acetaminophen DMUIE76 Approved Beta-N-acetylglucosaminidase (lytD) increases the Lysosomal storage disorders ADR of Acetaminophen. [1]
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References

1 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.