Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTZ5GHTQ)

DOT Name Sterile alpha motif domain-containing protein 7 (SAMD7)
Synonyms SAM domain-containing protein 7
Gene Name SAMD7
Related Disease
Retinitis pigmentosa ( )
UniProt ID
SAMD7_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF00536
Sequence
MAVNPLLTPTGQQTIPLIPSPFGPPTVDRDVLPSTVAPTDPRQFCVPSQFGSSVLPNTNM
ANVLSSRIYPGWGILPPESIKAVARRNEMIQRHHTARTEMEMYAIYQQRRMEKINPKGLA
GLGIPFLYGSSVPAAPAAYHGRSMLPAGDLHFHRSTLRNLQGNPMLAATAPHFEESWGQR
CRRLRKNTGNQKALDSDAESSKSQAEEKILGQTHAVPYEEDHYAKDPDIEAPSNQKSSET
NEKPTTALANTCGELEPTHRKPWGSHTTTLKAKAWDDGKEEASEQIFATCDEKNGVCPPV
PRPSLPGTHALVTIGGNLSLDEDIQKWTVDDVHSFIRSLPGCSDYAQVFKDHAIDGETLP
LLTEEHLRGTMGLKLGPALKIQSQVSQHVGSMFYKKTLSFPIRQAFDQPADTSPLLDPNS
WSDTMNIFCPQDTIIPKGIERGSMRN
Function Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.
Tissue Specificity Expressed in the retina (at protein level).

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Retinitis pigmentosa DISCGPY8 Strong Genetic Variation [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Permethrin DMZ0Q1G Approved Permethrin decreases the expression of Sterile alpha motif domain-containing protein 7 (SAMD7). [2]
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References

1 Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7.Sci Rep. 2016 Feb 18;6:21307. doi: 10.1038/srep21307.
2 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.