Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTZ63UYL)

DOT Name Olfactory receptor 10J5 (OR10J5)
Synonyms Olfactory receptor OR1-28
Gene Name OR10J5
Related Disease
Fatty liver disease ( )
UniProt ID
O10J5_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Pfam ID
PF13853
Sequence
MKRKNFTEVSEFIFLGFSSFGKHQITLFVVFLTVYILTLVANIIIVTIICIDHHLHTPMY
FFLSMLASSETVYTLVIVPRMLLSLIFHNQPISLAGCATQMFFFVILATNNCFLLTAMGY
DRYVAICRPLRYTVIMSKGLCAQLVCGSFGIGLTMAVLHVTAMFNLPFCGTVVDHFFCDI
YPVMKLSCIDTTINEIINYGVSSFVIFVPIGLIFISYVLVISSILQIASAEGRKKTFATC
VSHLTVVIVHCGCASIAYLKPKSESSIEKDLVLSVTYTIITPLLNPVVYSLRNKEVKDAL
CRVVGRNIS
Function
Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway. Acts also as a regulator of angiogenesis. Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway. May be involved in sperm chemotaxis and motility.
Tissue Specificity Expressed in both the aorta, the coronary artery and umbilical vein endothelial cells (HUVECs) (at protein level).
KEGG Pathway
Olfactory transduction (hsa04740 )
Reactome Pathway
Expression and translocation of olfactory receptors (R-HSA-9752946 )
Olfactory Signaling Pathway (R-HSA-381753 )

Molecular Interaction Atlas (MIA) of This DOT

1 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Fatty liver disease DIS485QZ Strong Biomarker [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Olfactory receptor 10J5 (OR10J5). [2]
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References

1 Olfactory receptor 10J5 responding to -cedrene regulates hepatic steatosis via the cAMP-PKA pathway.Sci Rep. 2017 Aug 25;7(1):9471. doi: 10.1038/s41598-017-10379-x.
2 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.