Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTZ8VP2Y)

DOT Name Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2)
Synonyms GPAT-2; EC 2.3.1.15; 1-acylglycerol-3-phosphate O-acyltransferase GPAT2; EC 2.3.1.51; xGPAT1
Gene Name GPAT2
Related Disease
Adrenomyeloneuropathy ( )
Melanoma ( )
Breast cancer ( )
Breast carcinoma ( )
Neoplasm ( )
UniProt ID
GPAT2_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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EC Number
2.3.1.15; 2.3.1.51
Pfam ID
PF19277
Sequence
MATMLEGRCQTQPRSSPSGREASLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWE
SLFHRSITDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDVPQKIMESTGV
QNLLSGRVPGGTGEGQVPDLVKKEVQRILGHIQAPPRPFLVRLFSWALLRFLNCLFLNVQ
LHKGQMKMVQKAAQAGLPLVLLSTHKTLLDGILLPFMLLSQGLGVLRVAWDSRACSPALR
ALLRKLGGLFLPPEASLSLDSSEGLLARAVVQAVIEQLLVSGQPLLIFLEEPPGALGPRL
SALGQAWVGFVVQAVQVGIVPDALLVPVAVTYDLVPDAPCDIDHASAPLGLWTGALAVLR
SLWSRWGCSHRICSRVHLAQPFSLQEYIVSARSCWGGRQTLEQLLQPIVLGQCTAVPDTE
KEQEWTPITGPLLALKEEDQLLVRRLSCHVLSASVGSSAVMSTAIMATLLLFKHQKLLGE
FSWLTEEILLRGFDVGFSGQLRSLLQHSLSLLRAHVALLRIRQGDLLVVPQPGPGLTHLA
QLSAELLPVFLSEAVGACAVRGLLAGRVPPQGPWELQGILLLSQNELYRQILLLMHLLPQ
DLLLLKPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQRLSRKLLWKPSGDFT
DSDSDDFGEADGRYFRLSQQSHCPDFFLFLCRLLSPLLKAFAQAAAFLRQGQLPDTELGY
TEQLFQFLQATAQEEGIFECADPKLAISAVWTFRDLGVLQQTPSPAGPRLHLSPTFASLD
NQEKLEQFIRQFICS
Function
Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.
KEGG Pathway
Glycerolipid metabolism (hsa00561 )
Glycerophospholipid metabolism (hsa00564 )
Metabolic pathways (hsa01100 )
Reactome Pathway
Triglyceride biosynthesis (R-HSA-75109 )
Synthesis of PA (R-HSA-1483166 )

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Adrenomyeloneuropathy DISPTS3P moderate Altered Expression [1]
Melanoma DIS1RRCY moderate Altered Expression [2]
Breast cancer DIS7DPX1 Limited Altered Expression [3]
Breast carcinoma DIS2UE88 Limited Altered Expression [3]
Neoplasm DISZKGEW Limited Altered Expression [3]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2). [4]
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References

1 Integrative lipidomic and transcriptomic analysis of X-linked adrenoleukodystrophy reveals distinct lipidome signatures between adrenomyeloneuropathy and childhood cerebral adrenoleukodystrophy.Biochem Biophys Res Commun. 2019 Jan 8;508(2):563-569. doi: 10.1016/j.bbrc.2018.11.123. Epub 2018 Nov 30.
2 Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line.PLoS One. 2014 Jun 26;9(6):e100896. doi: 10.1371/journal.pone.0100896. eCollection 2014.
3 Small non-coding RNA landscape is modified by GPAT2 silencing in MDA-MB-231 cells.Oncotarget. 2018 Jun 15;9(46):28141-28154. doi: 10.18632/oncotarget.25582. eCollection 2018 Jun 15.
4 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.