Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTZLRSDN)

DOT Name	Sperm acrosome-associated protein 5 (SPACA5)
Synonyms	EC 3.2.1.17; Lysozyme-like protein 5; Sperm-specific lysozyme-like protein X; SLLP-X
Gene Name	SPACA5
UniProt ID	LYZL5_HUMAN
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
EC Number	3.2.1.17
Pfam ID	PF00062
Sequence	MKAWGTVVVTLATLMVVTVDAKIYERCELAARLERAGLNGYKGYGVGDWLCMAHYESGFD TAFVDHNPDGSSEYGIFQLNSAWWCDNGITPTKNLCHMDCHDLLNRHILDDIRCAKQIVS SQNGLSAWTSWRLHCSGHDLSEWLKGCDMHVKIDPKIHP

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

1 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Permethrin	DMZ0Q1G	Approved	Permethrin increases the expression of Sperm acrosome-associated protein 5 (SPACA5).	[1]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene affects the methylation of Sperm acrosome-associated protein 5 (SPACA5).	[2]
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References

1	Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
2	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.