Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTZV8W66)

DOT Name	Prostaglandin E2 receptor EP1 subtype (PTGER1)
Synonyms	PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor
Gene Name	PTGER1
UniProt ID	PE2R1_CANLF
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Pfam ID	PF00001
Sequence	MSLCGPLNLSLAGEATPCAEPGAPNASAWPPSGRASASPALPIFSMTLGAVSNVLALALL AQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYAAGRSPAGGACHFLGGCM VFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSAARARLALAVLAALALAVALLPLARVG RYELQYPGTWCFIGLRPAGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRR RSRRRPQACGPDGRRHWGARAPRSASASSSSSVASVPGGSPGRGSARRARAHDVEMVGQL VGIMVVSCICWSPLLVLVVLAVGGWGSSSLQRPLFLAVRLASWNQILDPWVYILLRQAVL RQLLRLLPPRPGAKGSPAGLALTRSAWEASSLRSSRHSSLSHL
Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
Reactome Pathway	G alpha (q) signalling events (R-CFA-416476 ) Prostanoid ligand receptors (R-CFA-391908 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This DOT

This DOT Affected the Drug Response of 2 Drug(s)

Drug Name	Drug ID	Highest Status	Interaction	REF
Carbachol	DMX9K8F	Approved	Prostaglandin E2 receptor EP1 subtype (PTGER1) increases the Hypothalamus and pituitary gland disorders ADR of Carbachol.	[1]
Hydrochlorothiazide	DMUSZHD	Approved	Prostaglandin E2 receptor EP1 subtype (PTGER1) increases the Urinary abnormalities ADR of Hydrochlorothiazide.	[1]
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References

1	ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.