Details of the Drug Combination

General Information of Drug Combination (ID: DC0OJ1L)

Drug Combination Name

Voxilaprevir Velpatasvir

Indication

Disease Entry	Status	REF
Hepatitis C virus infection	Approved	[1]

Component Drugs

Voxilaprevir DMAI83D

Velpatasvir DMGF8ZQ

N.A.

2D MOL

3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Voxilaprevir Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]
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Voxilaprevir Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[3]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[4]
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Velpatasvir Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]
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Velpatasvir Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[5]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[6]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[7]
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References

1	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
2	Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition.
3	Management of Unique Populations with HCV Infection
4	FDA Label of Vosevi. The 2020 official website of the U.S. Food and Drug Administration.
5	Product characteristics of Epclusa.
6	FDA Label of Vosevi. The 2020 official website of the U.S. Food and Drug Administration.
7	Epclusa- European Medicines Agency - European Union