Details of the Drug Combination

General Information of Drug Combination (ID: DC18X7B)

• Drug Combination Name: Trimegestone + [3H]estrone-3-sulphate
• Indication: Menopause symptom; Status: Approved [1]
• Component Drugs:
  Trimegestone (DMHSZ1V): Small molecular drug
  [3H]estrone-3-sulphate (DMGPF0N): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Trimegestone

Disease Entry	ICD 11	Status	REF
Hormone replacement therapy	8E01	Approved	[1]

Indication(s) of [3H]estrone-3-sulphate

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[2]

[3H]estrone-3-sulphate Interacts with 6 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Sodium-independent organic anion transporter (SLCO1A2)	TTUGD21	SO1A2_HUMAN	Modulator	[3]
Organic anion transporter B (SLCO2B1)	TTDL3UZ	SO2B1_HUMAN	Modulator	[4]
Organic anion transporter F (SLCO1C1)	TT340CE	SO1C1_HUMAN	Modulator	[5]
Liver organic anion transporter 1 (SLCO1B1)	TTFGXEB	SO1B1_HUMAN	Modulator	[6]
Organic anion transporter E (SLCO4A1)	TTV1YIE	SO4A1_HUMAN	Modulator	[7]
Organic anion transporter D (SLCO3A1)	TT5CE6L	SO3A1_HUMAN	Modulator	[8]

[3H]estrone-3-sulphate Interacts with 6 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[9]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[10]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[11]
Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B)	DE10BJ5	UBS3B_HUMAN	Metabolism	[12]
Sulfatase (sulF)	DE7WRSB	A0A354WVI8_9BACT	Metabolism	[13]
Sulfatase (sulF)	DE9THM7	A0A1F0P5Q0_9BACT	Metabolism	[14]

[3H]estrone-3-sulphate Interacts with 20 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Decreases Expression	[15]
Platelet-derived growth factor subunit A (PDGFA)	OTCMZ0W8	PDGFA_HUMAN	Decreases Expression	[15]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Expression	[15]
Solute carrier family 22 member 12 (SLC22A12)	OT72ZAWS	S22AC_HUMAN	Increases Uptake	[16]
Organic anion transporter 3 (SLC22A8)	OT8BY933	S22A8_HUMAN	Increases Import	[17]
Solute carrier family 22 member 11 (SLC22A11)	OTAJLNJZ	S22AB_HUMAN	Increases Import	[18]
ABC-type organic anion transporter ABCA8 (ABCA8)	OTCWLX6N	ABCA8_HUMAN	Affects Transport	[19]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1)	OTERJ4VQ	SO2B1_HUMAN	Increases Import	[20]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Affects Export	[21]
Solute carrier family 22 member 6 (SLC22A6)	OTKRCBVM	S22A6_HUMAN	Increases Uptake	[22]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Increases Uptake	[23]
Sodium-dependent phosphate transport protein 4 (SLC17A3)	OTMJWIBM	NPT4_HUMAN	Affects Transport	[24]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Decreases Transport	[25]
Organic anion transporter 7 (SLC22A9)	OTO4BJCC	S22A9_HUMAN	Increases Import	[17]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2)	OTO70C5O	SO1A2_HUMAN	Increases Import	[26]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3)	OTOM3BUH	SO1B3_HUMAN	Increases Uptake	[27]
Sodium-dependent organic anion transporter (SLC10A6)	OTPMM183	SOAT_HUMAN	Increases Response To Substance	[28]
Dehydrogenase/reductase SDR family member 11 (DHRS11)	OTU3J0ZL	DHR11_HUMAN	Increases Reduction	[29]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Increases Export	[30]
Steryl-sulfatase (STS)	OTXTJQPC	STS_HUMAN	Decreases Sulfation	[31]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4748).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1219).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1224).
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1222).
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1220).
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1226).
• [8] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1225).
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