Details of the Drug Combination

General Information of Drug Combination (ID: DC25OME)

Drug Combination Name
TEM Pentostatin
Indication
Disease Entry Status REF
Lung adenocarcinoma Investigative [1]
Component Drugs TEM   DMLNFWU Pentostatin   DM0HXDS
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: EKVX
Zero Interaction Potency (ZIP) Score: 2.35
Bliss Independence Score: 5.97
Loewe Additivity Score: 8.03
LHighest Single Agent (HSA) Score: 1.6

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Indication(s) of Pentostatin
Disease Entry ICD 11 Status REF
Acute graft versus host disease 4B24.0 Approved [3]
Hairy cell leukaemia 2A82.2 Approved [4]
Leukemia N.A. Approved [3]
Pentostatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adenosine deaminase (ADA) TTLP57V ADA_HUMAN Inhibitor [5]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DCBR687 HL-60(TB) Investigative [6]
Clear cell renal cell carcinoma DCHZUNG A498 Investigative [6]
Glioma DCW8RMC SF-539 Investigative [6]
Carcinoma DC142LO RXF 393 Investigative [7]
Colon adenocarcinoma DC3IXES COLO 205 Investigative [7]
Invasive ductal carcinoma DCDWS2U HS 578T Investigative [7]
Adenocarcinoma DC7R8BR HCT-15 Investigative [1]
Amelanotic melanoma DCR6041 MDA-MB-435 Investigative [1]
High grade ovarian serous adenocarcinoma DCLK6HM OVCAR-8 Investigative [1]
Melanoma DC16Z77 MALME-3M Investigative [1]
Minimally invasive lung adenocarcinoma DC02LMR NCI-H322M Investigative [1]
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⏷ Show the Full List of 11 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 Pentostatin FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
5 Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
7 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165