Details of the Drug Combination

General Information of Drug Combination (ID: DC2DRC2)

• Drug Combination Name: Cabazitaxel + Dacarbazine
• Indication: Plasma cell myeloma; Status: Investigative [1]
• Component Drugs:
  Cabazitaxel (DMPAZHC): Small molecular drug
  Dacarbazine (DMNPZL4): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: RPMI-8226
  Zero Interaction Potency (ZIP) Score: 9.32
  Bliss Independence Score: 7.17
  Loewe Additivity Score: 2.83
  LHighest Single Agent (HSA) Score: 8.78

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Cabazitaxel

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Metastatic prostate carcinoma	N.A.	Investigative	[3]

Cabazitaxel Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[6]

Cabazitaxel Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[7]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[7]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[7]

Cabazitaxel Interacts with 2 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Affects Expression	[8]
Proline-rich AKT1 substrate 1 (AKT1S1)	OT4JHN4Y	AKTS1_HUMAN	Decreases Expression	[8]

Indication(s) of Dacarbazine

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[4]
Astrocytoma	2A00.0Y	Approved	[4]
Brain disease	8C70-8E61	Approved	[4]
Central nervous system disease	8A04-8D87	Approved	[4]
Glioblastoma	2A00	Approved	[4]
Gliosarcoma	N.A.	Approved	[4]
Melanoma	2C30	Approved	[5]
Classic Hodgkin lymphoma	N.A.	Investigative	[4]
Neuroblastoma	2D11.2	Investigative	[4]

Dacarbazine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Breaker	[10]

Dacarbazine Interacts with 3 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[11]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[12]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[13]

Dacarbazine Interacts with 12 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Increases Expression	[14]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[9]
Interferon regulatory factor 1 (IRF1)	OT43DI6J	IRF1_HUMAN	Increases Expression	[15]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Activity	[16]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Response To Substance	[17]
DNA repair nuclease/redox regulator APEX1 (APEX1)	OT53OI14	APEX1_HUMAN	Increases Response To Substance	[18]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Decreases Response To Substance	[19]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Response To Substance	[20]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Response To Substance	[20]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Affects Response To Substance	[21]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)	OTS3FVTY	M3K1_HUMAN	Decreases Response To Substance	[20]
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Decreases Response To Substance	[22]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DCXGTCW	DU-145	Investigative	[1]
Adenocarcinoma	DC2S3IK	A549	Investigative	[1]
Adenocarcinoma	DCJYYSM	HCT-15	Investigative	[1]
Adenocarcinoma	DCTRNQX	HCC-2998	Investigative	[1]
Adenocarcinoma	DCM6OFW	HT29	Investigative	[1]
Adult acute myeloid leukemia	DCNP7RV	HL-60(TB)	Investigative	[1]
Adult T acute lymphoblastic leukemia	DCR5F7O	MOLT-4	Investigative	[1]
Amelanotic melanoma	DCGBTQP	MDA-MB-435	Investigative	[1]
Anaplastic large cell lymphoma	DC417S5	SR	Investigative	[1]
Astrocytoma	DCYUI6W	SNB-19	Investigative	[1]
Clear cell renal cell carcinoma	DC6XWML	A498	Investigative	[1]
Clear cell renal cell carcinoma	DCQB8ZJ	786-0	Investigative	[1]
Clear cell renal cell carcinoma	DCOUMMF	TK-10	Investigative	[1]
Cutaneous melanoma	DCLIR66	SK-MEL-28	Investigative	[1]
High grade ovarian serous adenocarcinoma	DC44XUQ	OVCAR-8	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCQGC8I	NCI\\/ADR-RES	Investigative	[1]
Large cell lung carcinoma	DCM1NKR	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DCEN4IC	HOP-62	Investigative	[1]
Minimally invasive lung adenocarcinoma	DC1UO6U	NCI-H322M	Investigative	[1]
Non-small cell lung carcinoma	DC8JHPS	HOP-92	Investigative	[1]
Ovarian serous cystadenocarcinoma	DC69K05	SK-OV-3	Investigative	[1]
Papillary renal cell carcinoma	DCB02QZ	ACHN	Investigative	[1]
Prostate carcinoma	DC1AUE3	PC-3	Investigative	[1]
Renal cell carcinoma	DCKC144	SN12C	Investigative	[1]
Carcinoma	DCNKRT8	RXF 393	Investigative	[23]
Carcinoma	DCCJJ4J	MCF7	Investigative	[23]

References

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