Details of the Drug Combination

General Information of Drug Combination (ID: DC2PJCR)

Drug Combination Name
Safinamide mesylate Pyronaridine
Indication
Disease Entry Status REF
Hepatoblastoma Investigative [1]
Component Drugs Safinamide mesylate   DM0J2ZT Pyronaridine   DMUWAM2
N.A. Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: HB3
Zero Interaction Potency (ZIP) Score: 2.921
Bliss Independence Score: 3.642
Loewe Additivity Score: 2.154
LHighest Single Agent (HSA) Score: 3.401

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Safinamide mesylate
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [2]
Safinamide mesylate Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [2]
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Safinamide mesylate Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [4]
Monoamine oxidase type A (MAO-A) DERE4TU AOFA_HUMAN Metabolism [5]
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Indication(s) of Pyronaridine
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [3]
Pyronaridine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) TTZVSJ2 NOUNIPROTAC Inhibitor [6]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Disposition and metabolism of safinamide, a novel drug for Parkinson's disease, in healthy male volunteers. Pharmacology. 2013;92(3-4):207-16.
5 Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem. 2007 Oct 4;50(20):4909-16.
6 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.