Details of the Drug Combination

General Information of Drug Combination (ID: DC3KPRQ)

Drug Combination Name
ABIRATERONE Vinflunine
Indication
Disease Entry Status REF
Renal cell carcinoma Investigative [1]
Component Drugs ABIRATERONE   DM8V75C Vinflunine   DMTJAEP
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: UO-31
Zero Interaction Potency (ZIP) Score: 6.69
Bliss Independence Score: 12.14
Loewe Additivity Score: 13.42
LHighest Single Agent (HSA) Score: 13.69

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of ABIRATERONE
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
ABIRATERONE Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Steroid 17-alpha-monooxygenase (S17AH) TTRA5BZ CP17A_HUMAN Modulator [4]
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Indication(s) of Vinflunine
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [3]

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Anaplastic large cell lymphoma DC7X3W0 SR Investigative [1]
Clear cell renal cell carcinoma DCT9L6D TK-10 Investigative [1]
Glioma DC8N3X4 SF-539 Investigative [1]
Plasma cell myeloma DC2J084 RPMI-8226 Investigative [1]
Renal cell carcinoma DCY37RG SN12C Investigative [1]
Carcinoma DCLS1BG MCF7 Investigative [5]
Colon carcinoma DCYC3JI KM12 Investigative [5]
Adenocarcinoma DCR6EP8 OVCAR3 Investigative [6]
Adenocarcinoma DCTYQ2D NCIH23 Investigative [6]
Adenocarcinoma DCTG0NG HCT-15 Investigative [6]
Amelanotic melanoma DCR8ASR MDA-MB-435 Investigative [6]
Cutaneous melanoma DCRDCYK SK-MEL-28 Investigative [6]
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⏷ Show the Full List of 12 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976