Details of the Drug Combination

General Information of Drug Combination (ID: DC5B5FF)

Drug Combination Name
RTB101 Ciclopirox
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs RTB101   DM62QTW Ciclopirox   DMN5T2A
Small molecular drug Small molecular drug
High-throughput Screening Result Testing Cell Line: SU-DIPG-XIII
Zero Interaction Potency (ZIP) Score: 10.537
Bliss Independence Score: 11.475
Loewe Additivity Score: 8.934
LHighest Single Agent (HSA) Score: 10.221

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of RTB101
Disease Entry ICD 11 Status REF
Respiratory tract infection CA45 Phase 3 [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [3]
RTB101 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
CREB-regulated transcription coactivator 1 (TORC1) TT4GO0F CRTC1_HUMAN Inhibitor [6]
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Indication(s) of Ciclopirox
Disease Entry ICD 11 Status REF
Cutaneous candidiasis 1F23.14 Approved [4]
Fungal infection 1F29-1F2F Approved [5]
Mycoses 1F2Z Approved [4]
Onychomycosis EE12.1 Approved [4]
Pityriasis simplex N.A. Approved [4]
Tinea corporis 1F28.Y Approved [4]
Tinea cruris 1F28.3 Approved [4]
Tinea versicolor 1F2D.0 Approved [4]
Tinea pedis 1F28.2 Investigative [4]
Ciclopirox Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HIF-prolyl hydroxylase (HPH) TTJQFBG NOUNIPROTAC Modulator [7]
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Ciclopirox Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [8]
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References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2 ClinicalTrials.gov (NCT04139915) Effect of RTB101 on Illness Associated With Respiratory Tract Infections in the Elderly. U.S. National Institutes of Health.
3 ClinicalTrials.gov (NCT04409327) Phase 2 Study to Determine if RTB101 Reduces the Severity of COVID-19 in Older Adults Residing in Nursing Homes. U.S. National Institutes of Health.
4 Ciclopirox FDA Label
5 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076435.
6 Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
8 Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 2009 Oct 1;114(14):3064-73. doi: 10.1182/blood-2009-03-209965. Epub 2009 Jul 9.