Details of the Drug Combination

General Information of Drug Combination (ID: DC68SUY)

• Drug Combination Name: Casopitant + Warfarin
• Indication: Nausea and Vomiting, Chemotherapy-Induced; Status: Phase 1 [1]
• Component Drugs:
  Casopitant (DMBQYO0): Small molecular drug
  Warfarin (DMJYCVW): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Casopitant

Disease Entry	ICD 11	Status	REF
Chemotherapy-induced nausea	MD90	Withdrawn from market	[2]

Casopitant Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Substance-P receptor (TACR1)	TTZPO1L	NK1R_HUMAN	Antagonist	[6]

Indication(s) of Warfarin

Disease Entry	ICD 11	Status	REF
Atrial fibrillation	BC81.3	Approved	[3]
Deep vein thrombosis	BD71	Approved	[4]
Pulmonary hypertension	BB01	Approved	[4]
Thrombosis	DB61-GB90	Application submitted	[5]
Intracranial embolism	8B22.1	Investigative	[4]
Venous thromboembolism	BD72	Investigative	[4]

Warfarin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Vitamin K epoxide reductase complex 1 (VKORC1)	TTEUC8H	VKOR1_HUMAN	Inhibitor	[12]

Warfarin Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[13]

Warfarin Interacts with 8 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[14]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[15]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[11]
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Metabolism	[16]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Metabolism	[17]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[18]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[19]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[15]

Warfarin Interacts with 27 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Affects Response To Substance	[20]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3)	OTOM3BUH	SO1B3_HUMAN	Affects Response To Substance	[21]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Decreases Expression	[22]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Decreases Expression	[23]
Antithrombin-III (SERPINC1)	OTDFATG0	ANT3_HUMAN	Increases Expression	[24]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Affects Binding	[25]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Expression	[8]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[8]
Arylsulfatase L (ARSL)	OTF1VTCR	ARSL_HUMAN	Decreases Activity	[26]
Growth arrest-specific protein 6 (GAS6)	OTPOPUUE	GAS6_HUMAN	Decreases Carboxylation	[8]
Endomucin (EMCN)	OTS03CZC	MUCEN_HUMAN	Decreases Expression	[8]
Serine protease 53 (PRSS53)	OT3HUUI3	PRS53_HUMAN	Affects Response To Substance	[27]
Aspartyl/asparaginyl beta-hydroxylase (ASPH)	OT3KGDEE	ASPH_HUMAN	Affects Response To Substance	[28]
Myosin-6 (MYH6)	OT3YNCH1	MYH6_HUMAN	Affects Response To Substance	[29]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Affects Response To Substance	[30]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Affects Response To Substance	[31]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Increases Response To Substance	[8]
Transcription factor GATA-6 (GATA6)	OTO2BC0F	GATA6_HUMAN	Affects Response To Substance	[32]
Transcription factor GATA-4 (GATA4)	OTQHWAZG	GATA4_HUMAN	Affects Response To Substance	[32]
Fibroblast growth factor 5 (FGF5)	OTQXGHBY	FGF5_HUMAN	Affects Response To Substance	[33]
Calumenin (CALU)	OTSYQN71	CALU_HUMAN	Affects Response To Substance	[34]
Heme A synthase COX15 (COX15)	OTUIYHIW	COX15_HUMAN	Affects Response To Substance	[33]
Folylpolyglutamate synthase, mitochondrial (FPGS)	OTW3F1ZE	FOLC_HUMAN	Affects Response To Substance	[35]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Affects Response To Substance	[36]
Phospholipase DDHD1 (DDHD1)	OTWTHOWK	DDHD1_HUMAN	Affects Response To Substance	[28]
Vitamin K-dependent protein S (PROS1)	OTXQWNOI	PROS_HUMAN	Affects Response To Substance	[20]
Alpha-1-acid glycoprotein 1 (ORM1)	OTZKSBRE	A1AG1_HUMAN	Increases Response To Substance	[37]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5758).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6853).
• [4] Warfarin FDA Label
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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