General Information of Drug Combination (ID: DC6FI90)

Drug Combination Name
Casopitant Casopitant
Indication
Disease Entry Status REF
Nausea and Vomiting, Chemotherapy-Induced Phase 1 [1]
Component Drugs Casopitant   DMBQYO0 Casopitant   DMBQYO0
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Casopitant
Disease Entry ICD 11 Status REF
Chemotherapy-induced nausea MD90 Withdrawn from market [2]
Casopitant Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Substance-P receptor (TACR1) TTZPO1L NK1R_HUMAN Antagonist [3]
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Indication(s) of Casopitant
Disease Entry ICD 11 Status REF
Chemotherapy-induced nausea MD90 Withdrawn from market [2]
Casopitant Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Substance-P receptor (TACR1) TTZPO1L NK1R_HUMAN Antagonist [3]
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References

1 ClinicalTrials.gov (NCT00460707) A Study to Assess the Safety and Interaction Between Casopitant and Ketoconazole When Taken By Healthy Adults
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5758).
3 Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.