Details of the Drug Combination

General Information of Drug Combination (ID: DC6K1IF)

Drug Combination Name

Vinflunine Aminolevulinic Acid Hydrochloride

Indication

Disease Entry	Status	REF
Adult T acute lymphoblastic leukemia	Investigative	[1]

Component Drugs

Vinflunine DMTJAEP

Aminolevulinic Acid Hydrochloride DMWNHPC

Small molecular drug

2D MOL

3D MOL

3D MOL is unavailable

High-throughput Screening Result

Testing Cell Line: MOLT-4

Zero Interaction Potency (ZIP) Score: 9.52

Bliss Independence Score: 9.27

Loewe Additivity Score: 10.18

LHighest Single Agent (HSA) Score: 11.04

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Vinflunine

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Approved	[2]

Indication(s) of Aminolevulinic Acid Hydrochloride

Disease Entry	ICD 11	Status	REF
Actinic keratosis	EK90.0	Approved	[2]

Aminolevulinic Acid Hydrochloride Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Protoporphyrinogen oxidase (PPOX)	TTNFMS9	PPOX_HUMAN	Modulator	[3]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Astrocytoma	DCGGPX4	U251	Investigative	[1]
Breast adenocarcinoma	DCXI460	MDA-MB-468	Investigative	[4]
Amelanotic melanoma	DCM0FTK	MDA-MB-435	Investigative	[5]
High grade ovarian serous adenocarcinoma	DCT3M5R	NCI\\/ADR-RES	Investigative	[5]
------------------------------------------------------------------------------------

References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
5	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976