Details of the Drug Combination

General Information of Drug Combination (ID: DC7GC3E)

Drug Combination Name
PMID28870136-Compound-43 Altretamine
Indication
Disease Entry Status REF
High grade ovarian serous adenocarcinoma Investigative [1]
Component Drugs PMID28870136-Compound-43   DMWGV8N Altretamine   DMKLAYG
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: OVCAR-4
Zero Interaction Potency (ZIP) Score: 0.83
Bliss Independence Score: 5.54
Loewe Additivity Score: 4.19
LHighest Single Agent (HSA) Score: 2.91

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
PMID28870136-Compound-43 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Ecto-5'-nucleotidase (CD73) TTK0O6Y 5NTD_HUMAN Inhibitor [3]
------------------------------------------------------------------------------------
Indication(s) of Altretamine
Disease Entry ICD 11 Status REF
Ovarian cancer 2C73 Approved [2]
Altretamine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Breaker [4]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Childhood T acute lymphoblastic leukemia DC7LI19 CCRF-CEM Investigative [5]
Clear cell renal cell carcinoma DC2B90M TK-10 Investigative [5]
Glioblastoma DCI9JSL SNB-75 Investigative [5]
Invasive ductal carcinoma DCIGVWE HS 578T Investigative [6]
Adenocarcinoma DCNP4A6 HCT116 Investigative [1]
Cutaneous melanoma DCMW95C SK-MEL-5 Investigative [1]
High grade ovarian serous adenocarcinoma DCLVLNS OVCAR-8 Investigative [1]
Ovarian serous cystadenocarcinoma DCOOMVF SK-OV-3 Investigative [1]
Pleural epithelioid mesothelioma DC4J0U5 NCI-H226 Investigative [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7112).
3 Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
4 Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agen... Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165