Details of the Drug Combination

General Information of Drug Combination (ID: DC7LQBX)

• Drug Combination Name: Metaxalone +
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 17.98
  Bliss Independence Score: 17.98
  Loewe Additivity Score: 31.29
  LHighest Single Agent (HSA) Score: 31.31

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7609).