Details of the Drug Combination

General Information of Drug Combination (ID: DC8SE1C)

Drug Combination Name

Imiglitazar

Indication

Disease Entry	Status	REF
Type 2 Diabetes	Phase 3	[1]

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Imiglitazar

Disease Entry	ICD 11	Status	REF
Type-2 diabetes	5A11	Phase 3	[2]

Imiglitazar Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)	TTZMAO3	PPARG_HUMAN	Modulator	[3]
Peroxisome proliferator-activated receptor alpha (PPARA)	TTJ584C	PPARA_HUMAN	Modulator	[3]
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References

1	ClinicalTrials.gov (NCT04807348) Chiglitazar Added to Metformin for Type 2 Diabetes
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2675).
3	A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26.